NOTCH3 and lymphoma: Immunoblotting uncovered upregulation of Notch1/Notch3 in tumors from Lck-Dlx5 and Lck-Dlx5;Lck-MyrAkt2 mice, upregulation of Myc in tumors from Lck-Dlx5, Lck-MyrAkt2, and Lck-Dlx5;Lck-MyrAkt2 mice, and upregulation of β-catenin uniquely in lymphomas from Lck-Dlx5;Lck-MyrAkt2 mice (Fig. 1C).