DLX5 and lymphoma: Genes commonly up- or down-regulated in lymphoma cell lines from Lck-Dlx5;Lck-MyrAkt2 mice upon β-catenin inhibition are depicted in the Venn diagram shown in Supplementary Fig. S4A. Strikingly, genes encoding nearly all major components in the cholesterol synthesis pathway were upregulated (Supplementary Fig. S4B).