TP53 and lymphoma: Reactome pathway analysis identified Wnt, SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2) regulation of cholesterol biosynthesis, Notch, mTOR, cell cycle, and p53 as the major altered signaling pathways in Lck-Dlx5;Lck-MyrAkt2 lymphomas (Fig. 2B).