Genes commonly up- or down-regulated in lymphoma cell lines from Lck-Dlx5;Lck-MyrAkt2 mice upon β-catenin inhibition are depicted in the Venn diagram shown in Supplementary Fig. S4A. Strikingly, genes encoding nearly all major components in the cholesterol synthesis pathway were upregulated (Supplementary Fig. S4B). The gene discussed is LCK; the disease is lymphoma.