Collectively, these findings suggest that Wnt activity alone is sufficient to support T-ALL survival and proliferation, such that high levels of NOTCH, Hippo, and Hedgehog signaling genes as well as homeobox and mitogen genes are not required, although this does not rule out the possibility that those pathways are involved in Wnt activation earlier in disease development. This evidence concerns the gene LBX1 and acute lymphoblastic leukemia.