PGC1α is a neuroprotective mitochondrial biogenesis master regulator that plays a role in mitophagy and reactive oxygen species (ROS) reduction, often perturbed in PD25; Lamp2a is involved in chaperone-mediated autophagy (CMA) and has been shown to be reduced in post-mortem PD brains26. The gene discussed is PPARGC1A; the disease is Parkinson disease.