2005), mHTT may deregulate the entire process of stem cell-mediated neurogenesis and gliogenesis through impairments in the transcription (Feero and Hoffman 1995), such that mHTT can directly affect metabolic profiles in premanifest HD by altering mitochondrial biogenesis, maintenance, and function at the transcriptional level by inhibiting Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) (Cui et al. This evidence concerns the gene PPARGC1A and Huntington disease.