If BCL11A is disabled in erythroid precursors derived from edited hematopoietic stem cells, there is a robust induction of HbF.132,136,137 Very first patients with TDT and with SCD were treated with a CRISP/Cas9-mediated inactivation of BCL11A (Table 1, NCT03745287 and NCT03655678). The gene discussed is BCL11A; the disease is Schnyder corneal dystrophy.