It is now heavily documented that one of the important effects of ACE2 /Ang-(1–7)/mas receptor axis is on the brain and cerebral blood vessels [66], exerting protection against stroke [67] and there is evidence supporting the overall concept that the aging increases the sucseptivility of the cerebrovasculature to the effects of RAAS disbalance [68]. The gene discussed is ACE2; the disease is stroke disorder.