FTO and major depressive disorder: Engel et al. (2018) further elucidated the role of m6A in the context of stress response in adult mice. By examining mice with Mettl3 and Fto depletion in excitatory neurons they found alterations on m6A profiles with concomitant changes in transcriptome regulation, behavior, and electrophysiological properties (Engel et al., 2018). Importantly, they also reported that m6A regulation in blood could be used as a peripheral proxy of the brain’s m6A responses that are impaired in MDD patients (Engel et al., 2018).