Candidate variables for the first multivariable model were: age ≥ 60 years, sex, chronic lung disease, active cancer, BMI, LMWH administration, D-dimer at admission ≥ 1,000 ng/mL, C-reactive protein at admission ≥ 150 mg/L, ICU admission, worst PaO2:FiO2, and peak D-dimer ≥ 6,000. This evidence concerns the gene CRP and chronic lung disease.