P2X7 shows anti-adipogenic effects (170). P2X7 KO mice present increased body weight and adipocyte hyperplasia in fat pads (171). P2X7 is expressed on immune cells and their activation contributes with anti-inflammatory response. However, its expression during overweight or obesity has not been described (157). This evidence concerns the gene P2RX7 and obesity due to melanocortin 4 receptor deficiency.