INS and type 2 diabetes mellitus: Inflammation in T2D can be triggered by excessive levels of nutrients, like glucose, which leads to the local production and release of cytokines and chemokines: IL-1β, TNF-α, CC-chemokine ligand 2 (CCL2), CCL3 and CXC-chemokine ligand 8 (CXCL8) in the pancreatic islets and insulin-sensitive tissues.