INS and Hyperglycemia: In addition to the degree of hyperglycemia and the volume ratio α1, the following potential sources of variations in Δ[Na]/Δ[Glu] and therefore in corrected [Na] have been discussed: (a) differences in the apparent volumes of distribution of glucose and sodium due to intracellular entry of sodium ions, which is larger in some chronic illnesses than in the normal state (17), or to absence of insulin requirement for glucose uptake by the cells of certain organs, which was the source of the proposed value of −1.35 mmol/L per 5.6 mmol/L for Δ[Na]/Δ[Glu] (37).