SPAG5 and neoplasm: Astrin was also associated with tumor activity and prognosis in cervical, prostate, lung, bladder, and gastric cancer (Välk et al., 2010; Yuan et al., 2014; Zhang et al., 2016, 2020; Liu J. Y. et al., 2018; Song et al., 2018; Liu et al., 2019; Wang et al., 2019).