Inhibitors of mGluR5, which have been extensively studied in both preclinical research and in clinical trials, particularly as regards FXS and Parkinson’s disease (PD) (Gravius et al., 2010; Michalon et al., 2012; Scharf et al., 2015; Tison et al., 2016; Berry-Kravis et al., 2017), offer a potential repurposing strategy for COVID-19 (Figure 4). Here, GRM5 is linked to COVID-19.