F-box proteins are the substrate adaptors of S phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin-ligase complexes that mediate the degradation of a number of regulatory proteins involved in cancer processes including cell growth, cell division, signaling responses, and cell survival and death (Skaar et al., 2013). Here, SKP1 is linked to cancer.