Moreover since it has been reported that several mRNA m6A methyltransferases, including METTL3/14, WTAP, and RBM15/15B, participate in installation of m6A modification in mRNA (He et al., 2019), we postulated that, in addition to NAT10, other “writer(s)” exist that regulate ac4C acetylation in SLE, accounting for the generation of more ac4C-peaks or hyperacetylated mRNA. This evidence concerns the gene NAT10 and systemic lupus erythematosus.