Previous reports have described a strong relationship between mRNA modification and gene expression (Dai et al., 2018; Chen X. Y. et al., 2019; Yang et al., 2019; Han et al., 2020), and hence, we sought to characterize the functional role of the ac4C modification in mRNA of lupus CD4+ T cells. The gene discussed is CD4; the disease is systemic lupus erythematosus.