Furthermore, we identified that baicalin up-regulates the expression of DEPP (progesterone) and activates its downstream Ras/Raf/MEK/ERK and p16INK4A/Rb signaling pathways by acting as an antioxidant, leading to senescence in colon cancer cells (Wang et al., 2018). Here, DEPP1 is linked to malignant colon neoplasm.