Mice ALS models carrying mutations in SOD1, and Drosophila ALS models overexpressing TDP-43, both displayed ALS-like neurodegeneration that was rescued by the PPARγ agonist pioglitazone (Kiaei, 2008; Joardar et al., 2015). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.