For instance, breast cancer cells, stimulated by a pro-metastatic cue (e.g., transforming growth factor), shed the expression of epithelial signature genes (e.g., CDH1 encoding E-Cadherin) and simultaneously gain the expression of mesenchymal-specific genes (e.g., VIM encoding Vimentin) in a process known as epithelial-mesenchymal transition (EMT) to facilitate migration and invasion (Bill and Christofori, 2015). This evidence concerns the gene VIM and breast cancer.