SDC2 and cancer: Syndecan-2 has been implicated in diverse cellular events, including highly dynamic processes such as angiogenesis and cancer metastasis, but also in formation of mature structures like dendritic spines and control of ECM assembly, all of which appear to require the intact cytoplasmic domain (Ethell and Yamaguchi, 1999; Klass et al., 2000; Chen E. et al., 2004; Essner et al., 2006; Lee et al., 2011; Lim and Couchman, 2014).