It was reported that CIRBP had different effects in various cancers according to the cell context such as acting as a tumor suppressor in rectal carcinoma, endometrial carcinoma, and ovarian tumor and having pro-tumorigenic influences on melanoma, colorectal cancer, prostate cancer, central-nervous-system-related tumor, liver-pancreas carcinomas, skin squamous cell carcinoma, bladder cancer, and pituitary corticotrope adenoma (Zhu et al., 2016; Liao et al., 2017; Zhong and Huang, 2017; Chen et al., 2018; Colasanti et al., 2018; Lujan et al., 2018; Lin et al., 2019). This evidence concerns the gene CIRBP and skin squamous cell carcinoma.