Nowadays GPC3 is included in a diagnostic HCC panel together with glutamine synthetase and heat shock protein 70, according to guidelines of the European Society for Medical Oncology (ESMO) (Vogel et al., 2019) and the American Association for the Study of Liver Diseases (AASLD) (Marrero et al., 2018). The gene discussed is GPC3; the disease is hepatocellular carcinoma.