HPSE and breast carcinoma: Several studies have provided evidence that heparanase plays a major role in progression of a variety of cancers including liver cancer (Koliopanos et al., 2001), sarcomas (Cassinelli and Lanzi, 2020), ovarian cancer (Zhang et al., 2013), breast cancer (Maxhimer et al., 2005), and colon cancer (Nobuhisa et al., 2005).