In 2015, a study of perinatal female rat (F0) exposured to bisphenol A showed that the methylation of the imprinted gene insulin-like growth factor 2 (Igf2) of the F2 generation can be changed and cause intergenerational inheritance to impaire insulin secretion and glucose intolerance of the offspring (Mao et al., 2015). The gene discussed is IGF2; the disease is Glucose intolerance.