The ability of small molecule HDAC6 inhibitors (TubA, tubacin, ACY-1215 and NF2373) to restore cone photoreceptor vision was evaluated in atp6v0e1–/– zebrafish larvae, a genetic model of blindness potentially relevant to IRD and AMD (Figure 1A). The gene discussed is HDAC6; the disease is age-related macular degeneration.