STAT3 and neoplasm: Amberg et al. (2016) found that imiquimod treatment during late telogen can induce hair follicle stem cell activation and premature hair cycle entry. STAT3 is also highly phosphorylated in the psoriasis lesions (Calautti et al., 2018). Activation of STAT3 can promote wound healing, keratinocytes migration, hair follicle growth and participate in tumor occurrence (Sano et al., 2008). STAT3 phosphorylation has been shown to promote the proliferation of hair follicle stem/progenitor cells (Rao et al., 2015) and WIHN (Nelson et al., 2015).