Analyzing the CNS of sheep naturally infected with classical scrapie at clinical stage, we observed changes compatible with induction of autophagy in brain regions with low levels of prion-related lesions, such as basal ganglia and cerebellar Purkinje cells, which displayed an upregulation of both p62 and LC3 proteins (Lopez-Perez et al., 2019b). Here, SQSTM1 is linked to scrapie.