On the contrary, the encoded protein of FBXW7 is upregulated at the early stage of infection in the scrapie murine brain cell line SMB-S15 and in brains of scrapie-agent 263K-infected hamsters, leading to degradation of mTORC1 and increase of autophagic flux (Xu et al., 2016). This evidence concerns the gene FBXW7 and scrapie.