SCRG1 and sporadic Creutzfeldt-Jakob disease: Transcripts of SCRG1 (scrapie-responsive gene 1), whose encoded protein has been linked to the presence of autophagic vacuoles in neurons of scrapie-infected mice at terminal stage, are also enhanced in sporadic CJD (sCJD) and murine models of scrapie and BSE (Dandoy-Dron et al., 1998, 2000; Dron et al., 1998, 2005, 2006).