ACE2 and injury: About the relationship between ozone and Sars-CoV-2 is also worth noting the “triangle” existing among human angiotensin-converting enzyme 2 (ACE2), that both is a receptor facilitating virus entry and, as fundamental component of renin-angiotensin system, also protects from acute lung injury, and Nrf2 pathway modulation, influencing ACE2 activity and being in turn influenced by ozone (10, 11, 25–27).