For example, metformin, a drug commonly prescribed to type 2 diabetics, is an insulin sensitizer which targets complex I of the electron transport chain (El-Mir et al., 2000; Owen et al., 2000) and has been proposed as a supplementary therapy for Mtb which targets host metabolism (Oglesby et al., 2019). The gene discussed is INS; the disease is type 2 diabetes mellitus.