Furthermore, active TB was associated with increased levels of immunoglobulins, proteins associated with infiltration of neutrophils (MMP8, DEFA3, PRTN3), complement cascade members (C1QB, C1R, C1RL, C1S, C3, C4A, C5, C8A), and proteins playing a role in blood coagulation (F5, F13B, VWF, FGG, FGB, GP1BA). This evidence concerns the gene C8A and tuberculosis.