LBP and obesity due to melanocortin 4 receptor deficiency: Endotoxemia and its associated biomarkers (elevated LPS and LBP) were linked to increased risk of obesity and T2DM and correlated with disease exacerbation in humans (Mehta et al., 2010; Sun et al., 2010; Pussinen et al., 2011; Camargo et al., 2019).