α-2M, SAA1 and haptoglobin are markers associated with diabetic complications and duration of disease, and therefore reduction in these acute phase proteins might potentially be a mechanism of lowering the occurrence of complications in T2DM (Jonsson and Wales, 1976; McMillan, 1976; Mackellar and Vigerust, 2016). The gene discussed is HP; the disease is type 2 diabetes mellitus.