CD4 and infection: Additionally, CXCR3 was down regulated and CCR4 up regulated in memory CD4+ Treg exposed to ANDV-GP VLPs, this suggest that ANDV-GP could specifically act over CXCR3 in CD4+ Treg cells potentially altering their ability to migrate to the site of infection (Groom and Luster, 2011; Kallies and Good-Jacobson, 2017).