In order to assess cytotoxic effects of the drug OX on colon cancer cells in correlation to their p53 status, the wild-type p53 bearing HCT 116 cells and the mutant p53 bearing HT 29 cells were treated with OX (20 μM) and their cytotoxicity were measured by CCK8 assay after 24 and 48 h. This evidence concerns the gene TP53 and malignant colon neoplasm.