Though studies have reported the role of high Wnt activity as well as the involvement of Wnt/β-catenin signaling in regulating CSC properties (94–96), to our knowledge our study forms the first ever report demonstrating cancer stemness and Wnt/β-catenin signaling as factors contributing to the impaired sensitivity of the mutant p53 harboring colon cancer HT 29 cells to OX. Here, TP53 is linked to malignant colon neoplasm.