Indeed, the upregulation of the MHC class II receptor HLA-DR, the co-stimulatory molecules CD80 as well as CD86, and the co-activating receptor CD40 upon stimulation of monocytes with supernatants of treated CRC cells indicates the emergence of a potent APC phenotype which was most pronounced upon exposure to supernatants of CRC cells treated with HSP90i plus radiotherapy. The gene discussed is CD40; the disease is colorectal carcinoma.