GPX4 and neoplasm: Studies have shown that inhibition of ferroptosis displays protective effects against neurotoxicity (9–11), whereas, on the other hand, data are indicating that certain tumor cells depend on GPX4 and system Xc–, such as hepatocellular carcinoma (12, 13), pancreatic tumor (14, 15), breast cancer (16, 17), renal tumor (7, 18), and B cell lymphoma cells (7); therefore, inducing ferroptosis may represent novel strategies for anticancer treatment (4).