For example, circ-ANAPC7 participated in the occurrence and development of AML through the miR-181 family (43), circPAN3 mediated drug resistance through the miR-153-5p/miR-183-5p/XIAP axis (44), and circ-DLEU2 was involved in AML through the miR-496/PRKACB axis (48). The gene discussed is XIAP; the disease is acute myeloid leukemia.