This study showed that hsa_circ_0012152, which was upregulated in AML, was a promising classification biomarker to discriminate ALL from AML and might participate in the progression of AML through the miR-491-5p/EGFR/MAPK1 axis or the miR-512-3p/EGFR/MAPK1 axis. Here, MAPK1 is linked to acute myeloid leukemia.