In the ceRNA network, hsa_circ_0012152 shared miRNA response elements (MREs) of miR-491-5p with EGFR, MAPK1, PIK3R1, TP53, and POLR2C and shared MREs of miR-512-3p with EGFR, MAPK1, and CUL1. Importantly, the ceRNA network showed that hsa_circ_0012152 competed with EGFR and MAPK1 to combine miR-491-5p or miR-512-3p, indicating that hsa_circ_0012152 might involve in AML through miR-491-5p/EGFR/MAPK1 or miR-512-3p/EGFR/MAPK1 axis. This evidence concerns the gene MAPK1 and acute myeloid leukemia.