MMP1 and colonic neoplasm: However, no study analyzes if these cancer cells are able to form linear invadosomes when they are seeded on collagen I. As expected, proteases were peculiar of primary colon tumor: ADAM 9, 10, TSL1 and MMP1, 2, 9, 11, and 12 have been found solely in colon tumor (230) and not in the metastasis, suggesting their role in the migration process.