FN1 and neoplasm: One of their functions is to secrete various ECM elements including collagen I, fibronectin and hyaluronan, growth factors (HFG, PDGF, and CTGF), chemokines, cytokines, interleukines (IL-6 and IL-8) and proteases in order to promote tumor cell proliferation, angiogenesis and invasion (3, 27).