Collagen I → β1 integrin → MAPK → prosurvival signal CD44 → MDM2 nuclear translocation → Akt → tumor progression TGFB → collagen I → DDR1 → LOXL2 → Invadopodia Collagen I → DDR1 → Erk → SNAIL → EMT→ DDR2 → ERK → MMPs → Invasion. Here, AKT1 is linked to neoplasm.