Although the genetic causes of FCCTX are still unknown, several studies identified some CRC predisposing genes including BRCA2, SEMA4A, APC, BMPR1A, NTS, CDH18, RPS20, GREM1, BCR, KIF24, GALNT12, ZNF367, HABP4, GABBR2, TP53, SMAD4, and BMP4 (11–13, 22–24). The gene discussed is ZNF367; the disease is familial colorectal cancer type X.