In this study, we sorted the different myeloid cell subpopulations including PMN-MDSCs (CD33+HLA-DR−/lowCD14−CD15+), I-MDSCs (CD33+HLA-DR−/lowCD14−CD15−), M-MDSCs (CD33+HLA-DR−/lowCD14+CD15−), and monocytic APCs (CD33+HLA-DR+CD14+) from the circulation of CRC patients to investigate their transcriptomic characteristics, which could potentially contribute to disease progression. The gene discussed is CD33; the disease is colorectal carcinoma.