In the tumor environment, tumor and endothelial cells secrete various vascular factors to aggravate tumor angiogenesis, including vascular endothelial growth factor A (VEGFA), fibroblast growth factor-2 (FGF2), platelet-derived growth factor subunit A (PDGFA), hepatocyte growth factor (HGF), and hypoxia-inducible factor-1α (HIF-1α) (7–9). This evidence concerns the gene HIF1A and neoplasm.