MTOR and acute myeloid leukemia: In human cancer cell lines of acute lymphoblastic leukemia (ALL), AML, cervical, breast, colon, GBM, and kidney, the activity of mTOR is downregulated by MLN4924 in an almost dose-dependent manner, as evidenced with dephosphorylation of mTOR downstream targets such as p70S6 kinase (51, 93–95).