ClusterProfiler analysis found nine significantly enriched signaling pathways: protein digestion and absorption, ECM-receptor pathway, focal adhesion pathway, proteoglycans in cancer, human papillomavirus infection, platelet activation pathway, PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications, and amoebiasis (Figure 5A). This evidence concerns the gene AKT1 and human papilloma virus infection.