ARHGEF4 and colorectal carcinoma: Furthermore, Wang et al. reported that tumor DNA from AA CRC patients presented a significant difference in the number of methylated regions when compared with CRC tumors from CA patients (7), including four anti-inflammatory genes (NELL1, GDF1, ARHGEF4, and ITGA4) that could lead to differences in the inflammatory state of tumors from AA CRC patients (7).