Figures 2C,D show the 10 genes with the highest fold-change values of expression between tumor and non-tumor tissues for AAs and CAs, respectively. In accordance with our pathway analysis, the greatest differences in terms of fold-change of gene expression for AA include the cytokine genes IL1B and IL8 as well as the chemokine CXCL5. The fold-change values for the CA cohort showed NOTUM, FGF19, and PPBP (as the most significantly changed). PPBP encodes for pro-platelet basic protein) which correlates with the DNA replication pathway results from Figure 2A. Here, NOTUM is linked to neoplasm.