Furthermore, Wang et al. reported that tumor DNA from AA CRC patients presented a significant difference in the number of methylated regions when compared with CRC tumors from CA patients (7), including four anti-inflammatory genes (NELL1, GDF1, ARHGEF4, and ITGA4) that could lead to differences in the inflammatory state of tumors from AA CRC patients (7). This evidence concerns the gene NELL1 and colorectal carcinoma.