In this study, we utilized gene expression profiles (RNA-seq) and NanoString technology to demonstrate that CRC tumors from AA patients differ from CA patients in their gene expression patterns and immune cell recruitment, particularly those associated with T regulatory cells (higher FOXP3), pro-inflammatory cytokines (higher IL8 and IL1B), markers for cellular antitumor activity (lower GZMB and IFNG), as well as targets for immunotherapies (lower PDL1 and CTLA4). Here, CXCL8 is linked to colorectal carcinoma.