Furthermore, a genotype analysis in 65 samples using high-density single nucleotide polymorphism (SNP) arrays found associations between meningiomas and variation in PIAS2, KATNAL2, TCEB3C, TCEB3CL, and CTNNA3, especially TARDBP mutations with amyotrophic lateral sclerosis (21), which further improves the identification of susceptible sites of meningioma by genomics. The gene discussed is PIAS2; the disease is meningioma.