TIMP3 and meningioma: So far, methylation of TIMP3, CDKN2, and other genes that can regulate the progression of meningiomas have been identified by genome-wide methylation DNA analysis (37); further work reveals the connection between the H3K27me3 signal and hypermethylated phenotype in meningiomas, integrating with microarray analysis of the transcriptional network controlled by E2F2 and FOXM1. This study makes recommendations for potential targets for therapeutic intervention (38).