The first instance from a whole genome sequencing project of malignant subtypes revealed mutational signatures and frequently altered genes in malignant meningiomas, including NF2, MN1, ARID1B, SEMA4D, and MUC2, which confirmed the role of pathogenic NF2 mutations in the development of meningiomas, and expression of MN1 may be a valuable diagnostic tool for determining the potential in malignant transformation (28). This evidence concerns the gene MUC2 and meningioma.