In addition, proteins associated with apoptosis, caspase3, caspase8, Bax, and Bcl-2 were altered after knocking out EGFL6. Knockout of EGFL6 could inhibit the expression of N-cadherin, MMP9, MMP2, and vimentin and promote the expression of E-cadherin, which indicated that the knockout of EGFL6 may result in the inhibition of EMT in ovarian cancer cells. Here, MMP2 is linked to ovarian carcinoma.