Deleted in malignant brain tumors 1 (DMBT1) has been reported to be a tumor suppressor gene (TSG) in brain (medulloblastoma, GBM), lung, and gastrointestinal tumors based on homozygous deletions, lack of expression, its instability in cancer, and having key roles in immune defense and epithelial differentiation (47). This evidence concerns the gene DMBT1 and digestive system neoplasm.