In the current study, at the end of the follow-up period with median cut-off plasma levels of syndecan-1 of 160 ng/ml in AML cases, there was a significant difference in the median OS of patients with low plasma levels of syndecan-1 (14 months) and high plasma levels (four months; p = 0.044). The gene discussed is SDC1; the disease is acute myeloid leukemia.