ADA and Shwachman-Diamond syndrome: Supporting criteria include major criteria, which are positive family history and the discovery of a pathogenic mutation, and minor criteria, which are congenital anomalies, raised levels of erythrocyte adenosine deaminase (ADA), which are raised in 85% of cases, increased hemoglobin F, and exclusion of other syndromes of inherited bone marrow failure ( [IBMF] Fanconi’s syndrome, Shwachman-Diamond’s syndrome) [27].