Furthermore, the use of GSTs in vitro, in the context of HT-29 and LoVo cell cultures and in vivo, in the context of HT-29 tumor xenografts in athymic nude mice revealed that GSTs inhibit cancer cell growth (and volume increase), and upregulate Cip1/p21 expression (Kaur et al., 2006b). The gene discussed is HPGDS; the disease is neoplasm.