Furthermore, qRT-PCR results showed that HOTTIP and LINC00460 were upregulated (Figs. 8W and 8X), hsa-miR-206 was downregulated (Fig. 8Y) to varying degrees in many HNSCC cell lines (HN4, HN6, Cal27, HN30, SCC9, and SCC25). This evidence concerns the gene LINC00460 and head and neck squamous cell carcinoma.