TP53 and head and neck squamous cell carcinoma: More importantly, our study not only established three prognostic models consisting of prognostic RNAs, but also assessed the relationship between these prognostic models and conventional clinicopathological features (including TNM stage and histological grade) and specific HNSCC clinicopathological features (including TP53 mutation status, ALI, HPV status, PNI, and ECS).