Additionally, pluripotent stem cells pose a considerable cancer risk in the recipient, firstly through potential teratoma formation and secondly due to genetic alterations as a consequence to the usage of integrating vectors creating a risk for reactivation of commonly used reprogramming factors (OCT4, SOX2, MYC, and KLF4), which are also highly expressed in various cancer types25,29. The gene discussed is MYC; the disease is cancer.