Different from IgM antibody, a higher GMRT of IgG antibody was observed in patients with diabetes (P < 0.05) before the peak point (Fig. 1n), while significant higher GMRT of IgG was observed in patients with older age (P < 0.01, Fig. 1j), shorter days from symptom onset to admission (P < 0.001, Fig. 1l) or diabetes (P < 0.001, Fig. 1n) after the peak point. Here, CD40LG is linked to diabetes mellitus.