The above data on the normalization of tumor cells, as well as the fact that the administration of induced pluripotent stem cells into the embryo with a mutation leading to the downregulation of p53 with the simultaneous upregulation of growth/proliferative signaling pathways typical for embryonic stem cells (ESCs, which, when introduced into an extraembryonic environment, would highly likely lead to the formation of a tumor), resulted in to the development of a normal mouse [42]. Here, TP53 is linked to neoplasm.