KLK3 and Familial prostate cancer: In the recent report, serum [−2]proPSA (p2PSA), a serum isoform of PSA is moreaccurate than the reference standard tests (tPSA, fPSA, and %fPSA) in predictingprostate cancer in men aged <60 years and may also be indicative of cancer aggressiveness.36 Therefore, we will try to analyze whether p2PSA is a better maker notonly to detect Prostate cancer but also to estimate age.